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A better life for sensitive skin.
Home > Substiane [+] > SUBSTIANE [+] SERUM
Loss of volumes : sagging of facial features, loss of density, loss of bounce.

Mature and sensitive skin innovation:
- LR2412 + Pro-Xylane, an unique combination of highly concentrated active ingredients to help restore cutaneous volumes.
- A new generation of rich, creamy and melt-in serum texture, developed specifically for mature and sensitive skin which provides a “skin-holding” effect on skin.

Skin is denser, feels full to the touch. Day after day, its hold is strengthened.
As decrumpled, it is re-plumped, radiant and comfortable.

As a complement to your skincare. Morning and/or evening on the face and neck.
Tolerance tested under dermatological control on sensitive skin. Paraben-free.

45-54 years

Substiane Serum

I have rosacea, sensitive and very fair skin. I have used La Roche-Posay products for several years now successfully. I have just started using this particular product a few days ago now. It glides on easily, no tugging or pulling on the skin which is important to me. A different sort of sent, but it doesn't bother me. So far, so good. Will post an update in about a month.

40-49 years


As a 38 year old, I have started to notice some volume loss in my face. Particularly in the cheek & naso labial fold areas. This product claims to restore substance & structure deep within the skin cells. After 2 weeks of use, I can't say I've noticed an incredible difference, however, my skin does feel more radiant & feels somewhat full to the touch. I believe with continued use I will be able to see a substantial improvement with the plumpness in my problem areas. Oh, my skin does look softer!

65-74 years

awesome product!

I have used this product for 2 full weeks and I am delighted with it.It claims to combine two anti-aging formulas which will create a brand new way to restore substance and structure in the depths of the skin cells, making skin feel denser, full to the touch, re-plumped, and radiant as well as comfortable. I found all these claims to be true, and at 64 the healthy look of my skin is very important to me, both as a woman and as a singer and artist who wants to look her best with healthy skin